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KMID : 0369820070370060349
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Jorunal of Korean Pharmaceutical Sciences
2007 Volume.37 No. 6 p.349 ~ p.354
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Polymer Effects on Appetite Suppression by Lipoic Acid Nanoparticles
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Choi Hye-Min
Parkk Chul-Ho
Lee Ki-Up
Park Joong-Yeol
Koh Eun-Hee
Kim Hyun-Sik
Lee Jong-Hwi
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Abstract
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For decades, the various virtues of acid (ALA), a natural material synthesized in most cells, have been intensively studied and proved. Recently it was reported that ALA caused significant bodyweight reduction via appetite suppression. Unfortunately, the efficacy requires an administration over 50 mg/kg. The low bioavailability and the short plasma half life of ALA lead us to explore novel pharmaceutical dosage forms using nanoparticles. In this study, the effect of polymeric stabilizers on the bioavailability improvement of ALA nanoparticles was investigated. The reduction of particle size via nano-comminution technology was successful resulting in volume average particle sizes of 320 - 340 nm. The in vitro release rate of ALA did not reflect the decrease of particle size, possibly because of the self polymerization of ALA during nano-comminution. The type of polymeric stabilizers could not affect the release rate either. However, the in vivo food intake results of ALA showed that nano-suspensions were more effective than microparticles or a salt form. The nano-suspension containing polyvinyl pyrrolidone as the primary stabilizer and polyacrylic acid as the secondary stabilizer showed more improved efficacy for 2 hours.
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KEYWORD
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acid, Appetite suppression, Bioavailability, Polymer, Nanoparticles
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